Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
All Product Categories
-
Drug Derivative Inhibitors
(12)
View all products
-
Drug Derivative Agonist
(1)
View all products
-
Drug Derivative Activator
(1)
View all products
-
Drug Derivative Chemical
(1)
View all products
-
Drug Derivative Inducer
(1)
View all products
-
Drug Derivative Controls
(38)
View all products
-
Drug Derivative Substrate
(1)
View all products
-
Drug Derivative Related Products (4056)
Related Products (4056)
-
D-Cysteic acid
0 ImagesCat. No.: HY-W736050CAS No.: 35554-98-4D-Cysteic acid is a competitive inhibitor of the aspartate:alanine antiporter (AspT) from Tetragenococcus halophilus. For L-aspartate self-exchange, D-Cysteic acid has a Ki of 0.14 mM and an IC50 of 0.19 mM; for L-alanine self-exchange, it has a Ki of 5.0 mM and an IC50 of 9.0 mM. D-Cysteic acid occupies a distinct substrate-binding site within the substrate transport pathway of AspT, preventing the binding of natural substrates to the transporter. D-Cysteic acid can be used in studies related to substrate recognition and transport mechanisms of transporters.
-
WAY-322454
0 ImagesWAY-322454 is an active molecule.
-
Mardepodect precursor
0 ImagesCat. No.: HY-169773CAS No.: 871507-11-8Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs.
-
Omeprazole sulfone N-oxide
0 ImagesCat. No.: HY-138199CAS No.: 158812-85-2Omeprazole sulfone N-Oxide is an Omeprazole (HY-B0113) analog with binding affinity to Nilaparvata lugens choline acetyltransferase (ChAT).
-
4'-Fluoro diazepam
0 ImagesCat. No.: HY-168358CAS No.: 52357-79-64'-Fluoro diazepam is a 1,4-benzodiazepine compound. 4'-Fluoro diazepam is structurally similar to Diazepam, but its has only minimal biological activity.
-
7,7-Azo-3-α,12-α-dihydroxycholanic acid
0 ImagesCat. No.: HY-W706341CAS No.: 86992-52-17,7-Azo-3-α,12-α-dihydroxycholanic acid is a photoinactive (photopolymerization) derivative of Cholic acid (HY-N0324), and it has a relatively low affinity for high-density lipoprotein (HDL).
-
Diethylene glycol cyclic phthalate
0 ImagesCat. No.: HY-W587858CAS No.: 13988-26-6Diethylene glycol bis phthalate is a phthalate ester and is used as plasticizers.
-
1,3-Dimethylnaphthalene
0 ImagesCat. No.: HY-W087908CAS No.: 575-41-71,3-Dimethylnaphthalene is a Naphthalene (HY-Y0602) derivative. 1,3-Dimethylnaphthalene induces hatching of cod larvae.
-
Asulacrine isethionate
0 ImagesCat. No.: HY-13552CAS No.: 80841-48-1Synonyms: CI-921 isethionate; NSC 343499 isethionateAsulacrine isethionate (CI-921 isethionate) is a derivative of Amsacrine (HY-13551), a Topoisomerase II inhibitor and an anticancer agent. Asulacrine isethionate binds to DNA via intercalation, forming stable complexes with long residence times at DNA sites. Asulacrine isethionate mediates DNA breakage and DNA-protein cross-linking. Asulacrine isethionate exhibits anticancer activity against leukemia or lung cancer. Asulacrine isethionate can be used in research related to breast cancer, lung cancer, mouse solid tumors and leukemia.
-
2,5-DMMA
0 ImagesCat. No.: HY-172060CAS No.: 54687-43-32,5-DMMA is classified as a phenethylamine.
-
Ingenol 3-Hexanoate
0 ImagesCat. No.: HY-111533CAS No.: 83036-61-7Ingenol 3-Hexanoate, an ingenol semi-synthetic derivative, is a potent anticancer agent. Ingenol 3-Hexanoate can be used in research of cancer.
-
K-TMZ
0 ImagesCat. No.: HY-115690CAS No.: 2269482-26-8K-TMZ is a derivative of methyl ketone, which exhibits antitumor efficacy against O6 -methylguanine DNA methyltransferase (MGMT) deficient cell. K-TMZ can be used for research of glioblastoma.
-
1-Propinoyl Lysergic acid methylisopropylamide
0 ImagesCat. No.: HY-150342CAS No.: 3028950-73-1Synonyms: 1P-MiPLA1-Propinoyl Lysergic acid methylisopropylamide (1P-MiPLA) is a lysergamide compound.
-
Dimethyl octadecanedioate
0 ImagesSynonyms: Octadecanedioic acid,dimethyl esterDimethyl octadecanedioate (Octadecanedioic acid,dimethyl ester) is an ester product.
-
L-Ascorbyl myristate
0 ImagesCat. No.: HY-121860CAS No.: 33425-76-2L-Ascorbyl myristate is a bioactive compound with notable chemical properties.
